In 2016, an investment of $10,000 in Alphabet (GOOG) and continuous monthly investments of an average cost of $350 over ten years would now be worth approximately $365,000. This vividly demonstrates Warren Buffett's long-term holding principle. The 1-for-20 stock split of Alphabet in 2022 and persistent investing amidst market volatility are key to achieving a 7x return, highlighting the importance of patience in holding stocks over reacting to short-term fluctuations.